Platelet-rich fibrin (PRF) is a second-generation autologous platelet aggregation biomaterial with a wide range of applications in medicine and dentistry. PRF is already frequently used for procedures such as bone grafting and sinus augmentation, but its application can extend to surgical and nonsurgical endodontic procedures as well. This handbook, the first of its kind, is designed to help the clinician understand and use PRF in endodontics. It discusses the science, clinical applications, and techniques for specialists and general practitioners in a concise, easy-to-read format. The applications for PRF for each endodontic procedure are laid out step-by-step with accompanying photographs and case studies.