This revised and expanded edition highlights the importance of understanding the biologic and psychologic pain mechanisms to prepare clinicians who treat patients presenting with a variety of pain symptoms. The authors include evidence-based research on how the pain experience may be influenced by genetics, gender, or individual psychosocial and health histories. Extending well beyond basic toothache and TMDs, this book covers pathologic conditions of surrounding orofacial structures and nonodontogenic pain disorders that may manifest as orofacial pain as well. Chapters on management guide clinicians on how to develop practical and compassionate treatment plans based on logical evaluation methods, accurate diagnosis, and appropriate pharmacologic treatment, or how to decide when referral to other health care providers is warranted. A series of case studies demonstrates the effective application of this information to clinical situations.