Entrepreneurial ecosystems involve a complex synergy of factors, including social and structural changes that are frequently cumulative within territories, promoting the improvement of citizens’ quality of life and higher development levels. Further, dynamic territories are characterized by constant change, activity and progress. Each chapter in this volume examines a specific entrepreneurial ecosystem in an effort to describe why and how certain companies and organizations manage to overcome adversities and achieve strong performance, while others fail. Unlike the conventional focus, the volume examines microenterprises and Small and Medium Enterprises (SMEs), while also discussing selected experiences and case studies from developed and developing countries alike.